Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery.Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and produce a limited region of therapeutic effect.In this study, we introduce a novel mode of ocular g